Diphenhydramine Hydrochloride is the hydrochloride salt form of diphenhydramine, an ethanolamine and first-generation histamine antagonist with anti-allergic activity. Diphenhydramine, or Diphenylhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative. Although generally considered sedating, diphenhydramine can cause paradoxical central nervous system stimulation in some individuals, particularly at higher doses. Learn about Diphenhydramine HCl, an antihistamine used for allergy relief, treating cold symptoms, motion sickness, and insomnia. Includes dosage, side effects, precautions, and drug interactions. Diphenhydramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Allergy (Diphenhydramine HCl) is an antihistamine that is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms. Allergy (Diphenhydramine HCl) is also used to treat motion sickness, to induce sleep, and to treat certain symptoms of Parkinson's disease. Diphenhydramine is a prescription medication used to treat the symptoms of an allergic reaction, insomnia, cough, motion sickness, and parkinsonism. Learn about side effects, dosages, drug interactions, warnings, and more. Diphenhydramine is used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and other cold or allergy symptoms. Diphenhydramine is also used to treat motion sickness, to induce sleep, and to treat certain symptoms of Parkinson's disease. Diphenhydramine hydrochloride is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, itching, watery eyes, itchy eyes/nose/throat, cough, runny nose, and sneezing. Learn about diphenhydramine usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Find patient medical information for Diphenhydramine (Benadryl, Unisom, and others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings.